Rodent Langendorff Apparatus

The Langendorff apparatus is designed to sustain the cardiac function of isolated hearts with gravity-fed, constant perfusion pressure and are available in both recirculating and non-recirculating configurations.

They come in various sizes to accommodate different heart sizes, including those of mice, rats, guinea pigs, rabbits, and cats.

SKU: A-LANG-R Category:

Langendorff apparatuses are designed to sustain the cardiac function of isolated heart preparations through gravity-fed constant perfusion pressure, and they come in both recirculating and non-recirculating models. Constant pressure perfusion allows for monitoring of variations in heart resistance and activity through changes in flow rate, making it particularly useful in ischemia-reperfusion (IR) studies, cardiac physiology, pathology, pharmacology, and myocardial biochemistry and metabolism. With its high repeatability and stability, this system ensures reliable research results.

These apparatuses are also available in various sizes to accommodate different species, including mouse, rat, guinea pig, rabbit, and cat.

Key Features

  • Sturdy lab stand assembly and all associated clamp hardware
  • High-grade Tygon perfusion tubing engineered to prevent perfusate degassing under low-flow conditions.
  • A water-jacketed reservoir facilitates temperature control and continuous gas equilibration of the perfusion medium.
  • A water-jacketed bubble trap effectively eliminates entrained air from the fluid stream, ensuring uninterrupted flow.

Applications

  • Cardiomyocyte Isolation
  • In Vitro tissue engineering studies
  • Electrophysiological assessments (ECG, MAP, electrical and optical mapping)
  • Myocardial contractility analysis
  • Pharmacological safety testing (hemodynamics, cardiac arrest protocols)
  • Cardiac disease modeling, including atrial fibrillation, ischemia-reperfusion injury, myocardial infarction, ventricular fibrillation
  • Investigation of cardiac dysfunction caused by diabetes and hypertension

Have Questions?

The iWorx team is here to help—whether you have a quick question or need hands-on support. Our technical specialists offer one-on-one assistance with setup, troubleshooting, and optimizing your system.

Design Your System

Choose the parameters you want to Measure

ECG/EKG
EMG : Number of Channels
Non-Invasive BP : Number of Channels
Flow : Number of Channels
Temperature: Number of Channels
Force: Number of Channels
Stimulation: Describe the type

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