LabScribe PVLoop Analysis Module

The LabScribe PV Loop Module can be used to analyze pressure-volume data from any source including conductance catheters, admittance catheters or sonomicrometry dimension crystals.

SKU LS-PVL Category Software

Pressure-volume (PV) loops have become the gold standard for studying myocardial contractility, compliance, muscle energetics and other quantitative measures of cardiac function. Typical applications for PV loops include heart failure studies, gene therapy and manipulation protocols and pharmacology studies.

iWorx offers a comprehensive acquisition and analysis solution for PV loop experiments. The foundation of these systems is the LabScribe Pressure-Volume Loop Module which allows for real-time display and analysis of elastance and compliance curves providing instant feedback on the quality of occlusions being performed. Unlike other software offerings for PV analysis, all the acquisition and analysis takes place within one program providing seamless and time saving options for generating data for publication.

The LabScribe PV Loop Module can be used to analyze pressure-volume data from any source including conductance catheters, admittance catheters, echo ultrasound systems or sonomicrometry dimension crystals. Data from other recorders and compatible echo ultrasound systems can be imported into LabScribe using the import module for analysis.

Compatible with Millar Pressure Volume Loop set up

Citations

230

PVLoop papers on
Google Scholar cite iWorx.

Pressure Volume Loops Analysis

LabScribe Pressure Volume Loop Module

LS-PVL: iWorx Pressure Volume Loop Software Module is a plug-in software module for iWorx data acquisition systems that performs pressure volume loop analysis for hemodynamic research in animals. The software module provides a powerful and easy to use tool for investigators to measure and analyze the hemodynamic parameters of cardiac and pulmonary pressure and volume data acquired by an iWorx recorder.

Cardiac cycle parameters that can be monitored online are:

Heart Rate,
End Systolic Pressure,
End Diastolic Pressure,
Max Pressure,
Min Pressure,
Max dP/dt,
Min dP/dt,
Max Volume,
Min Volume,
End Systolic Volume,
End Diastolic Volume,
Stroke Volume,
Cardiac Output,
Ejection Fraction,
Stroke Work

Further analysis can be performed offline, such as selecting cycles, calculating Pressure-Volume Area, Potential Energy, Cardiac Efficiency, and plotting PV Loops, PRSW, Max dp vs EDV, PVA vs EDV, PVA vs ESP, can be performed. The data and graphs can be copied or exported to the built-in Journal or any external program.

The software module is plug and play compatible with all iWorx Data Acquisition and Analysis Modules.

Notable Features:

Real-time XY plotting
Real-time analysis of PV derived parameters
Real-time or offline calculation of admittance derived volume using raw signals from the Scisense ADVantage system
Calibration of classical conductance catheter volume using cuvette method or Baan’s equation
Volume calculations from sonomicrometry, echo ultrasound or pressure-volume systems
Calculation of stress-volume loops from VisualSonics echo ultrasound data

PV Loop Calculations:

Maximum and Minimum Volume
Diastolic and Systolic Volume
Stroke Volume
Cardiac Output
Ejection Fraction
End-Systolic Pressure Volume Relationship (ESPVR)
End-Diastolic Pressure Volume Relationship (EDPVR)
Preload-Recruitable Stroke Work (PRSW)
Pressure-Volume Area (PVA)
Arterial Elastance
Time-Varying Elastance
Maximum Power
Preload-Adjusted Maximal Power
Potential Energy
Cardiac Efficiency
Heart Rate Variability (HRV) Calculations

Plotting:

PV Loops
PRSW
Max dp/dt vs EDV
PVA vs EDV
PVA vs ESP
Time Varying Elastance
E(t) vs. time
Averaged PV loops

Detailed information about using the modules is in the LabScribe Manual

Videos

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Related Software Modules

LS-TXT The iWorx Import Module enables import of data in text format that was recorded in any other data acquisition program. The module also allows the researcher to use the analysis functions in LabScribe software on data they may previously recorded with another a different program.

LS-BP The LabScribe Blood Pressure Module acquires and analyzes data from blood pressure transducers. Data can be analyzed from ventricular and arterial signals in real-time. The software automatically calculates common indices of function from the blood pressure signal where it can easily be exported to another program for further analysis.